ParkinsonCanadaV1, Main, Exploration, bibRecord, 002890

Vitamins and entacapone in levodopa-induced hyperhomocysteinemia : A randomized controlled study

Identifieur interne : 002890 ( Main/Exploration ); précédent : 002889; suivant : 002891

Vitamins and entacapone in levodopa-induced hyperhomocysteinemia : A randomized controlled study

Auteurs : R. B. Postuma [Canada] ; A. J. Espay [Canada] ; C. Zadikoff [Canada] ; O. Suchowersky [Canada] ; W. R. W. Martin [Canada] ; A.-L. Lafontaine [Canada] ; R. Ranawaya [Canada] ; R. Camicioli [Canada] ; A. E. Lang [Canada]

Source :

Neurology [ 0028-3878 ] ; 2006.

RBID : Pascal:06-0352311

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Hyperhomocystéinémie, Vitamine, Entacapone, Lévodopa.
Wicri :
- topic : Vitamine.

English descriptors

KwdEn :
- Entacapone, Hyperhomocysteinemia, Levodopa, Nervous system diseases, Vitamin.

Abstract

Elevated homocysteine is associated with increased risk of heart disease, stroke, and dementia. Therapy of Parkinson disease (PD) with levodopa elevates homocysteine. The authors conducted a 6-week, multicenter, randomized, double-blind, placebo-controlled trial to test whether folate 1 mg/ vitamin B₁₂ 500 μg or entacapone reduced serum homocysteine in 35 levodopa-treated PD patients. Levodopa initiation caused a small elevation in homocysteine. Vitamin therapy, but not entacapone, resulted in a decrease in homocysteine compared to placebo.

Affiliations:

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Le document en format XML

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<author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital</s1>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Entacapone</term>
<term>Hyperhomocysteinemia</term>
<term>Levodopa</term>
<term>Nervous system diseases</term>
<term>Vitamin</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Hyperhomocystéinémie</term>
<term>Vitamine</term>
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<front><div type="abstract" xml:lang="en">Elevated homocysteine is associated with increased risk of heart disease, stroke, and dementia. Therapy of Parkinson disease (PD) with levodopa elevates homocysteine. The authors conducted a 6-week, multicenter, randomized, double-blind, placebo-controlled trial to test whether folate 1 mg/ vitamin B<sub>12</sub>
 500 μg or entacapone reduced serum homocysteine in 35 levodopa-treated PD patients. Levodopa initiation caused a small elevation in homocysteine. Vitamin therapy, but not entacapone, resulted in a decrease in homocysteine compared to placebo.</div>
</front>
</TEI>
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<region><li>Québec</li>
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<settlement><li>Montréal</li>
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<orgName><li>Université McGill</li>
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<tree><country name="Canada"><region name="Québec"><name sortKey="Postuma, R B" sort="Postuma, R B" uniqKey="Postuma R" first="R. B." last="Postuma">R. B. Postuma</name>
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<name sortKey="Camicioli, R" sort="Camicioli, R" uniqKey="Camicioli R" first="R." last="Camicioli">R. Camicioli</name>
<name sortKey="Espay, A J" sort="Espay, A J" uniqKey="Espay A" first="A. J." last="Espay">A. J. Espay</name>
<name sortKey="Lafontaine, A L" sort="Lafontaine, A L" uniqKey="Lafontaine A" first="A.-L." last="Lafontaine">A.-L. Lafontaine</name>
<name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name>
<name sortKey="Martin, W R W" sort="Martin, W R W" uniqKey="Martin W" first="W. R. W." last="Martin">W. R. W. Martin</name>
<name sortKey="Ranawaya, R" sort="Ranawaya, R" uniqKey="Ranawaya R" first="R." last="Ranawaya">R. Ranawaya</name>
<name sortKey="Suchowersky, O" sort="Suchowersky, O" uniqKey="Suchowersky O" first="O." last="Suchowersky">O. Suchowersky</name>
<name sortKey="Zadikoff, C" sort="Zadikoff, C" uniqKey="Zadikoff C" first="C." last="Zadikoff">C. Zadikoff</name>
</country>
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</record>

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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Vitamins and entacapone in levodopa-induced hyperhomocysteinemia : A randomized controlled study

Vitamins and entacapone in levodopa-induced hyperhomocysteinemia : A randomized controlled study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri